Open Hardware/Software Leads to a Better Behavioral Tasks

Ooh Ooh Ooh! They Finally Did It! So this has been a GREAT week in research. A new protocol was reported for building an open-hardware/open-software operant chamber for testing rats called the ArduiPod Box. Now I have been planning and scheming on how to do this for ages, but never got around to it. I … More Open Hardware/Software Leads to a Better Behavioral Tasks

Perceptual vs Memory Pattern Separation? Dentate Gyrus Holds the Key!

So there has been a long discussion going at PatternSeparation.com about what role the hippocampus and nonhippocampal cortices play for pattern separation. A new paper is available that adds an interesting wrinkle in this discussion by revealing a novel type of nonspatial patern separation in the hippocampus of rodents. The data also suggest there may be two types of patern separation. depending upon the demands of the behavioral task.

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Neurocognitive Endophenotypes in CGG KI and Fmr1 KO Mouse Models

So in this post I want to talk about a theoretical review paper I published not long ago. This paper is important to me for a couple of reasons: 1) It serves as a logical extension to my theoretical work wherein I first claimed to demonstrate a behavioral endophenotype in CGG KI mice. I suggested in this paper that I would be able to predict where the *Fmr1* KO would compare based on the molecular genetics. And 2) The data I used in this review came from a series of studies from another laboratory using behavioral tasks I developed .

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Great Behavioral Tasks can Validate Mouse Models of Autism

In this post I want to discuss an example of when behavioral testing on a mouse model of human disease is done entirely correct. In this case, the right task was chosen for mice, and was developed in very close collaboration with the clinician whose work in humans was being modeled by the mice. This approach, called endophenotyping, actually studies non-core features of autism in a mouse model, but rather models cognitive processing in human autism using a mouse model. … More Great Behavioral Tasks can Validate Mouse Models of Autism